Published January 2013
| Version v1
Journal article
Apoptosis mediated by caspase-3 and p53-dependent anticancer effects of 159Gd-DTPA-BMA complex
Creators
- 1. Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais (Brazil). Faculdade de Farmacia
- 2. Centro de Desenvolvimento da Tecnologia Nuclear-Comissao Nacional de Energia Nuclear, Belo Horizonte, Minas Gerais (Brazil)
Description
In this work the apoptosis mediated by caspase-3 and p53-dependent anticancer effects of 159Gd-DTPA-BMA metal complex were evaluated against RT2 glioblastoma cells. The results showed that the mechanism of cell death involves apoptosis by caspase-3 activation. Furthermore, the involvement of p53 protein triggered by 159Gd-DTPA-BMA in these cells was verified preliminarily. Considering these finding, the radioactive complex can be considered as potential therapeutic alternative agent against cancer. (author)
Additional details
Publishing Information
- Journal Title
- Journal of Radioanalytical and Nuclear Chemistry
- Journal Volume
- 295
- Journal Issue
- 1
- Journal Page Range
- p. 63-66
- ISSN
- 0236-5731
- CODEN
- JRNCDM
INIS
- Country of Publication
- Hungary
- Country of Input or Organization
- Hungary
- INIS RN
- 44033758
- Subject category
- S60: APPLIED LIFE SCIENCES; S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Descriptors DEI
- BRAZILIAN ORGANIZATIONS; ENZYME ACTIVITY; ENZYMES; GADOLINIUM 159; GADOLINIUM COMPLEXES; GLIOMAS; NEOPLASMS
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; COMPLEXES; DISEASES; EVEN-ODD NUCLEI; GADOLINIUM ISOTOPES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOTOPES; NATIONAL ORGANIZATIONS; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEI; ORGANIC COMPOUNDS; PROTEINS; RADIOISOTOPES; RARE EARTH COMPLEXES; RARE EARTH NUCLEI
Optional Information
- Notes
- 17 refs.