Published March 1979 | Version v1
Journal article Metadata-only

Radioprotective effectiveness of mercapto acetamidines and possible biochemical mechanisms fo their effect

Creators

Description

A study was made of the radioprotective properties of some mercapto acetamidines, namely: chlorhydrate 2-mercapto acetamidine, dichlorhydrate bis-(2-acetamidino) disulfide and chlorhydrate N-(1-adamantine) 2-mercapto acetamidine. These compounds were all shown to possess a pronounced radioprotective efficiency when administered intraperitonelally and orally. The data are presented on the dynamics of distribution of 35S-mercapto acetamidine among organs and tissues of mice 5, 15, 30, 60 and 120 min after intraperitoneal administration theoreof. To all appearance, the increase in the SH-group content of the spleen plays an essential part in the mechanism of the radioprotective effect of mercapto acetamidine

Additional details

Additional titles

Original title (Russian)
Радиозащитные свойства меркаптоацетамидинов и возможные биохимические механизмы их действия

Publishing Information

Journal Title
Radiobiologiya
Journal Volume
19
Journal Issue
2
Series
Radiobiologiya.
Journal Page Range
235-240
ISSN
0033-8192

INIS

Country of Publication
Russian Federation
Country of Input or Organization
USSR
INIS RN
11508207
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Numerical Data
Descriptors DEI
BIOCHEMISTRY; EXPERIMENTAL DATA; GAMMA RADIATION; GRAPHS; INTRAPERITONEAL INJECTION; LABELLED COMPOUNDS; MICE; ORAL ADMINISTRATION; ORGANS; RADIOPROTECTIVE SUBSTANCES; SULFUR 35; TABLES; THIOLS; TIME DEPENDENCE; TOXICITY
Descriptors DEC
ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CHEMISTRY; DATA; DATA FORMS; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTROMAGNETIC RADIATION; EVEN-ODD NUCLEI; INFORMATION; INJECTION; INTAKE; IONIZING RADIATIONS; ISOTOPES; LIGHT NUCLEI; MAMMALS; NUCLEI; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RADIATIONS; RADIOISOTOPES; RESPONSE MODIFYING FACTORS; RODENTS; SULFUR ISOTOPES; VERTEBRATES

Optional Information

Notes
For English translation see the journal Radiobiology (USA).