Published December 1998
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Optimization of Samarium-153 labeled Hydroxyapatite Particles as Therapeutic Agent for Radiation Synovectomy
- 1. Isotope Production Div., Office of Atomic Energy for Peace, Bangkok (Thailand)
Description
Hydroxyapatite (HA) was studied as a particular carrier for beta-emitting radionuclides in radiation synovectomy. Particles were labeled with 153Sm (T1/2 = 46.7 hrs., β-energy = 810 (20%), 710(50%), 640(30%) keV, γ-energy = 103.2 (29.8%) KeV, range in tissue = 2.5 mm). Labeling efficiency was greater than 95%, pH 4-6, sterile and pyrogen free, stability is 6 days and in vivo studies by intra-articular injection into knee of normal rats showed the total cumulative leakage of 153Sm over 6 days was around 2% ID, The ease of preparation of 153Sm-HA, efficiency of labeling and low leakage from the joint make 153Sm-HA attractive for radiation synovectomy
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Additional details
Publishing Information
- Imprint Title
- Proceedings of the 7. Nuclear Science and Technology Conference
- Imprint Pagination
- 666 p.
- Journal Page Range
- [11 p.]
- Report number
- INIS-TH--007
Conference
- Title
- 7. Conference on Nuclear Science and Technology
- Dates
- 1-2 Dec 1998
- Place
- Bangkok (Thailand)
INIS
- Country of Publication
- Thailand
- Country of Input or Organization
- Thailand
- INIS RN
- 30041197
- Subject category
- S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- DRUGS; EXPERIMENTAL DATA; SAMARIUM 153
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; DATA; DAYS LIVING RADIOISOTOPES; EVEN-ODD NUCLEI; INFORMATION; INTERMEDIATE MASS NUCLEI; ISOTOPES; NUCLEI; NUMERICAL DATA; RADIOISOTOPES; RARE EARTH NUCLEI; SAMARIUM ISOTOPES