Acetylcholine of rat brain under acute radiation affection

A two - fold increase in acetylcholine, that can randomly be released by brain synaptosomes, is registered 60 min following whole-body X-irradiation of rats with a dose of 0.21 C/kg; depolarization of the synaptosome membranes by potassium chloride increases the release of acetylcholine the augmentation of the release in this case being lower than that in the control. The initial rate of spontaneous neutromediator release from synaptosomes grows by 80 per cent wheres after depolarization of synaptosome membranes by potassium chloride, by 15 per cent. There is a 2.5 - fold increase in the maximum rate of a highly specific uptake of choline with Km value being constant. Acetylcholine content of gray substance of irradated rat brain in invariable