Published April 2023 | Version v1
Journal article Metadata-only

Angiogenesis imaging of adrenocortical carcinoma with Ga-68-NODAGA-RGD positron emission tomography: opening new horizons in multimodality imaging from theranostic perspective

Creators

  • 1. Radiation Medicine Centre, Bhabha Atomic Research Centre, Trombay, Mumbai (India)
  • 2. Clinical Nuclear Medicine, Homi Bhabha National Institute, Mumbai (India)
  • 3. Department of Surgery, Seth G. S. Medical College and King Edward Memorial Hospital, Mumbai (India)

Description

A 53-year-old female, with a known case of adrenocortical carcinoma (ACC), underwent F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for initial staging, which revealed FDG avid large left suprarenal mass contiguous with hypermetabolic tumor thrombus in the inferior vena cava (IVC) through the left renal vein. Thereafter, she underwent angiogenesis imaging using Ga-68-NODAGA-RGD PET/CT, which showed similar avid tracer uptake in both primary and IVC thrombus. Demonstration of RGD avidity in ACC in this case opens a new horizon for targeted radionuclide therapy (e.g., Lu-177 RGD) in selected patients, who may have limited therapeutic options. (author)

Additional details

Identifiers

DOI
10.4103/ijnm.ijnm_186_22;

Publishing Information

Journal Title
Indian Journal of Nuclear Medicine
Journal Volume
38
Journal Issue
2
Journal Page Range
p. 183-184
ISSN
0972-3919

INIS

Country of Publication
India
Country of Input or Organization
India
INIS RN
54080142
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
ACTH; CARCINOMAS; FLUORINE 18; GALLIUM 68; LUTETIUM 177; POSITRON COMPUTED TOMOGRAPHY; RADIOISOTOPE SCANNING; RADIOPHARMACEUTICALS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; GALLIUM ISOTOPES; HORMONES; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; LUTETIUM ISOTOPES; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; PROTEINS; RADIOACTIVE MATERIALS; RADIOISOTOPES; RARE EARTH NUCLEI; TOMOGRAPHY