Published September 2018 | Version v1
Journal article Metadata-only

Preclinical study of an 18F-labeled glutamine derivative for cancer imaging

Creators

  • 1. Peking University-Tsinghua University Center for Life Sciences, Beijing 100871 (China)
  • 2. Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China)

Description

The emerging evidence that demonstrated the extra-demand of glutamine for cancer surviving strongly called for the development of PET tracer for imaging glutamine uptake in cancer. In this work, [18F]Gln-BF3 as a natural glutamine derivative was synthesized to explore its potential application of imaging glutamine uptake for cancer diagnosis.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2018.06.007

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2018.06.007;
PII
S0969805118301306;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
64
Journal Page Range
p. 34-40
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
55042920
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
BORON FLUORIDES; DIAGNOSIS; FLUORINE 18; GLUTAMINE; ISOTOPIC EXCHANGE; LABELLING; NEOPLASMS; POSITRON COMPUTED TOMOGRAPHY; UPTAKE
Descriptors DEC
AMIDES; AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BORON COMPOUNDS; BORON HALIDES; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORIDES; FLUORINE COMPOUNDS; FLUORINE ISOTOPES; HALIDES; HALOGEN COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOISOTOPES; TOMOGRAPHY

Optional Information

Copyright
Copyright (c) 2018 Elsevier Inc. All rights reserved.