Investigation of health risks related with multipath entry of groundwater nitrate using Sobol sensitivity indicators in an urban-industrial sector of south India

In the present study, we used a variance decomposition based global sensitivity index to evaluate the sensitivity of input variables and their contribution for non-carcinogenic health risks via intake and dermal pathways. Groundwater samples were collected from an industrial sector (Tiruppur region) of south India during the month of January 2020. These samples were analysed for nitrate, which varied from 10 to 290 mg L⁻¹ having the mean of 87 mg L⁻¹. Nearly 58% of the samples surpassed the permissible limit (45 mg L⁻¹) defined by the World Health Organization. Total hazard index (THI) ranged from 0.29 to 8.52 for children, 0.28 to 8.26 for women, and 0.24 to 6.99 for men. The first-order effect (FOE) and second-order effect (SOE) were derived for the three different age groups using Sobol sensitivity approach. The FOE scores showed that nitrate concentration in groundwater is the most sensitive parameter followed by exposure frequency for children, men and women via oral pathway. The SOE scores showed that nitrate concentration along with ingestion rate had greater sensitiveness in the oral input model. The higher SOE was obtained for the interaction of nitrate with skin surface area for children via dermal pathway, but it was not significant for women and men. These results suggest that epidemiology due to nitrate risk should be studied taking into account of concentration of nitrate, exposure frequency, fraction of contact and body weight. Additionally, ingestion rate and skin surface area were considered for the assessment of health risks for children.