Bio-availability of I-125 in the rabbit eye and the influence of a sodium iodide solution on human cataract lens in vitro
Description
The studies on hand show the bio-availability of iodine in animal tests, and the findings in human cataract lenses to indicate a stabilizing effect of iodine on lens proteins. One decisive fact produced by the findings of this study is that bio-availability of iodine does not depend on the iodine salt alone but that it is enhanced by both oxidizing and reducing agents. Glucose - an oxidizing agent - results in an increase of bio-availability by a factor of five as against potassium iodide alone; sodium thiosulphate - a strongly reducing agent - results in an increase of bio-availability by a factor of eleven. Similarly, sodium thiosulphate has a positive effect on the stabilizing action of iodine on the human caract lens at in-vitro incubation. (orig./MG)
Availability note (English)
MF available from INIS under the Report Number.Abstract (German)
Die vorliegenden Untersuchungen lassen einerseits nun im Tierversuch erkennen, dass eine Bioverfuegbarkeit vorliegt; andererseits zeigen die Befunde an menschlichen Kataraktlinsen, dass dem Jod eine stabilisierende Wirkung auf Linsenproteine zukommt. Ein entscheidender Befund der vorliegenden Untersuchungen stellt auch die Feststellung dar, dass die Bioverfuegbarkeit von Jod nicht vom Jodsalz allein abhaengig ist, gesteigert wird sie durch oxydierende, aber auch reduzierende Mittel. Glucose, das einen oxydierenden Stoff darstellt, fuehrt zu einer fuenffachen Erhoehung der Bioverfuegbarkeit gegenueber Kaliumjodid allein, und Natriumthiosulfat, das ein stark reduzierendes Mittel darstellt, hat eine elffache Erhoehung der Bioverfuegbarkeit zur Folge. (orig./MG)
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Additional details
Additional titles
- Original title (German)
- Bioverfuegbarkeit von
Publishing Information
- Imprint Pagination
- 52 p.
- Report number
- INIS-mf--9861
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 17016456
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Thesis
- Descriptors DEI
- EYES; GLUCOSE; IN VITRO; IN VIVO; IODIDES; IODINE 125; MAN; METABOLISM; POTASSIUM IODIDES; RABBITS; RADIONUCLIDE KINETICS; UPTAKE
- Descriptors DEC
- ALDEHYDES; ALKALI METAL COMPOUNDS; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HALIDES; HALOGEN COMPOUNDS; HEXOSES; INTERMEDIATE MASS NUCLEI; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPES; KINETICS; MAMMALS; MONOSACCHARIDES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; POTASSIUM COMPOUNDS; PRIMATES; RADIOISOTOPES; SACCHARIDES; SENSE ORGANS; VERTEBRATES