Production of tungsten-188 and osmium-194 in a nuclear reactor for new clinical generators
Creators
- 1. Nuclear Medicine Group, Health and Safety Research Div., Oak Ridge National Lab., TN (United States)
Description
Rhenium-188 and iridium-194 are potential candidates for radioimmunotherapy with monoclonal antibodies directed against tumor-associated antigens. Both nuclei are short-lived and decay by high energy β- emission. In addition, both nuclei emit γ-rays with energy suitable for imaging. An important characteristic is availability of 188Re and 194Ir from decay of reactor-produced parents (188W and 194Os, respectively) in covenient generator systems. The 188W and 194Os are produced by double neutron capture of 186W and 192Os, respectively. The large scale production yields of 188W in several nuclear reactors will be presented. We also report a new measurement for the cross-section of 193Os(n, γ)194Os reaction and discuss the feasibility of producing sufficient quantities of 194Os. (orig.)
Additional details
Publishing Information
- Publisher
- Springer.
- Imprint Place
- Berlin (Germany)
- ISBN
- 3-540-55100-X
- Imprint Title
- Nuclear data for science and technology
- Imprint Pagination
- 1060 p.
- Series
- Research reports in physics.
- Journal Page Range
- p. 595-597.
Conference
- Title
- International conference on nuclear data for science and technology.
- Dates
- 13-17 May 1991.
- Place
- Juelich (Germany).
INIS
- Country of Publication
- Germany
- Country of Input or Organization
- Germany
- INIS RN
- 23083233
- Subject category
- S07: ISOTOPES AND RADIATION SOURCES; S73: NUCLEAR PHYSICS AND RADIATION PHYSICS; S73: NUCLEAR PHYSICS AND RADIATION PHYSICS;
- Resource subtype / Literary indicator
- Conference, Numerical Data
- Descriptors DEI
- BETA-MINUS DECAY; CAPTURE; EXPERIMENTAL DATA; FFTF REACTOR; GAMMA RADIATION; HFBR REACTOR; HFIR REACTOR; INTEGRAL CROSS SECTIONS; IRIDIUM 194; ISOTOPE PRODUCTION; MURR REACTOR; NEUTRON REACTIONS; OSMIUM 192 TARGET; OSMIUM 193; OSMIUM 193 TARGET; OSMIUM 194; PHOTONS; RESEARCH REACTORS; RHENIUM 188; TUNGSTEN 186 TARGET; TUNGSTEN 187; TUNGSTEN 188
- Descriptors DEC
- BARYON REACTIONS; BETA DECAY; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BOSONS; CROSS SECTIONS; DATA; DAYS LIVING RADIOISOTOPES; DECAY; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; ENRICHED URANIUM REACTORS; EPITHERMAL REACTORS; EVEN-EVEN NUCLEI; EVEN-ODD NUCLEI; FAST REACTORS; HADRON REACTIONS; HEAVY NUCLEI; HEAVY WATER COOLED REACTORS; HEAVY WATER MODERATED REACTORS; HOURS LIVING RADIOISOTOPES; INFORMATION; INTERNAL CONVERSION RADIOISOTO; IONIZING RADIATIONS; IRIDIUM ISOTOPES; IRRADIATION REACTORS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE PRODUCTION REACTORS; ISOTOPES; LIQUID METAL COOLED REACTORS; MASSLESS PARTICLES; MINUTES LIVING RADIOISOTOPES; NUCLEAR DECAY; NUCLEAR REACTIONS; NUCLEI; NUCLEON REACTIONS; NUMERICAL DATA; ODD-ODD NUCLEI; OSMIUM ISOTOPES; RADIATIONS; RADIOISOTOPES; REACTORS; RESEARCH AND TEST REACTORS; RHENIUM ISOTOPES; SODIUM COOLED REACTORS; TANK TYPE REACTORS; TARGETS; TEST FACILITIES; TEST REACTORS; THERMAL REACTORS; TRAINING REACTORS; TUNGSTEN ISOTOPES; WATER COOLED REACTORS; WATER MODERATED REACTORS; YEARS LIVING RADIOISOTOPES