Published 1995
| Version v1
Journal article
Radiosensitizer AK-2123 as modulating agent in the chemotherapy of experimental metastases
- 1. Institute of Chemical Physics of Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region (Russian Federation)
- 2. Kinki Invention Center, Yoshida Kawaramachi-cyo 14 Sakyo-ku, Kyoto 606 (Japan)
Description
Therapeutic effect of Cyclophosphamide (CPA) and radiosensitizer AK-2123 (AK) combination versus CPA alone in the same dose was investigated on transplanted LL carcinoma and B 16 melanoma. Anti-metastatic efficacy of different doses of CPA and combined therapy was evaluated. Our data demonstrate that the effect of combined treatment by CPA at low un-effective doses (60 mg kg-1, 40 mg kg-1, 20 mg kg-1 at the 3 rd and the 7th day after transplantation) and AK at low daily doses (1 mg kg-1 and 0.1 mg kg-1 for 3-9 days after transplantation) is equal or superior to the effect of CPA alone at the therapeutic dose (120 mg kg-1). (author)
Additional details
Publishing Information
- Journal Title
- Neoplasma
- Journal Volume
- 42
- Journal Issue
- 3
- Journal Page Range
- p. 119-122
- ISSN
- 0028-2685
INIS
- Country of Publication
- Slovakia
- Country of Input or Organization
- Slovakia
- INIS RN
- 29060800
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- CARCINOMAS; CHEMOTHERAPY; COMBINED THERAPY; DISEASE INCIDENCE; EXPERIMENTAL DATA; INHIBITION; LUNGS; MELANOMAS; METASTASES; RADIOLOGY; RADIOSENSITIZERS; RADIOTHERAPY; STATISTICAL DATA; TRANSPLANTS
- Descriptors DEC
- BODY; CARCINOMAS; DATA; DISEASES; DRUGS; EPITHELIOMAS; INFORMATION; MEDICINE; NEOPLASMS; NUMERICAL DATA; ORGANS; RESPIRATORY SYSTEM; RESPONSE MODIFYING FACTORS; THERAPY
Optional Information
- Notes
- 2 figs., 2 tabs., 11 refs.