Published February 1992 | Version v1
Journal article Metadata-only

Production of 6-[18F]fluoro-L-DOPA and its metabolism in vivo -a critical review

Creators

  • 1. Universite Libre de Bruxelles (Belgium). Hopital Erasme
  • 2. Liege Univ. (Belgium). Centre de Recherches du Cyclotron
  • 3. California Univ., Los Angeles, CA (United States). Lab. of Nuclear Medicine and Radiation Biology
  • 4. Hammersmith Hospital, London (United Kingdom). M.R.C. Cyclotron Unit
  • 5. Turku Medical Cyclotron Project (Finland)
  • 6. Aabo Akademi Accelerator Lab., Turku (Finland)
  • 7. Max-Planck-Institut fuer Neurologische Forschung, Koeln (Germany)

Description

This report critically appraises methods for the synthesis of 6-[18F ]fluoro-L-3,4-dihydroxyphenylalanine (6-FDOPA) that are based on labelling by non-regioselective electrophilic fluorination, regioselective fluorodemetalation or nucleophilic substitution. Recommendations for the standardization of labelling procedures, the optimization of radiochemical yield and the assurance of product quality and safety are given. Studies of the metabolism of 6-FDOPA in vivo are also reviewed to emphasize the importance of the biochemical component of the development of this tracer for positron emission tomography (PET). (Author)

Additional details

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
19
Journal Issue
2
Series
Nucl. Med. Biol.
Journal Page Range
149-158
ISSN
0883-2897
CODEN
NMBIE

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
23071633
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
CHEMICAL PREPARATION; DOPA; FLUORINE 18; IN VIVO; LABELLING; METABOLISM; POSITRON COMPUTED TOMOGRAPHY; QUALITY CONTROL; RADIOPHARMACEUTICALS
Descriptors DEC
AMINO ACIDS; AUTONOMIC NERVOUS SYSTEM AGENT; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; COMPUTERIZED TOMOGRAPHY; CONTROL; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY ACIDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NEUROREGULATORS; NUCLEI; ODD-ODD NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY