Synthesis, spectroscopy, crystallography and biological activity of organotin complexes of oxygen and sulfur containing ligands

A series of di organotin (IV) complexes of B-diketones of general formula R/sub 2/SnL/sub 2/ where R=CH/sub 3/, C/sub 4/H/sub 9/, C/sub 6/H/sub 5/ and L=1,3-diphenyl-1,3-propane dione and 1-phenyl 1,3-butane dione (I-VI) have been prepared by reactions of di organotin dichloride with the sodium salt of the respective ligands in the 1.2 molar ratio. All the compounds have been characterised by elemental analysis, IR, 1H, 13C and /sup 119/Sn, NMR, mass and /sup 119/Sn Moessbauer spectroscopy. The cytotoxicity, anti fugal, anti bacterial activity have been studied. In addition to this, antitumor activity against various tumours have been studied and it has been found that dibutyl tin derivative is highly active against different cancers. A series of organotin (IV) complexes of general formulae R/sub 3/SnL (R=C/sub 6/H/sub 5/, C/sub 6/H/sub 5/CH/sub 2/, C/sub 6/H/sub 11/, C/sub 4/H/sub 9/, CH/sub 3/); and R/sub 2/SnL/sub 2/: (R=C/sub 6/H/sub 5/, C/sub 6/H/sub 5/CH/sub 2/, C/sub 4/H/sub 9/, CH/sub 3/); where L=2-thio naphthalene have been synthesized. All of these have been characterized by elemental analysis, IR, 1H, /sup 13/C, /sup 119/Sn NMR, Mass, Moessbauer spectroscopy and X-ray crystallography. The crystal data for four compound have been found. The biocidal activity and cytotoxicity of these complexes have been studied against various bacteria and fungi. (author)