Published August 1984
| Version v1
Journal article
In vivo and in vitro mechanisms of radiation sensitization, drug synthesis and screening: can we learn it all from the high dose data
Description
The evidence for a decreased enhancement ratio of oxygen and an electron affinic radiosensitizer (misonidazole) at low doses is presented, and the mechanism of this effect is discussed. The factors which influence the magnitude of this effect, as well as the dose levels at which the effect will be significant, are identified. This will allow further characterization of this phenomenon in the future. An approach by which present and new hypoxic radiosensitizers could be made more effective at low doses is indicated
Additional details
Publishing Information
- Journal Title
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Volume
- 10
- Journal Issue
- 8
- Series
- Int. J. Radiat. Oncol., Biol. Phys.
- Journal Page Range
- 1185-1193
- ISSN
- 0360-3016
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16030316
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- DOSE-RESPONSE RELATIONSHIPS; LOW DOSE IRRADIATION; MATHEMATICAL MODELS; MISONIDAZOLE; OXYGEN; OXYGEN ENHANCEMENT RATIO; PHARMACOLOGY; RADIOSENSITIVITY; SURVIVAL CURVES
- Descriptors DEC
- ALCOHOLS; ANTINEOPLASTIC DRUGS; AZOLES; DRUGS; ELEMENTS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; IRRADIATION; NITRO COMPOUNDS; NONMETALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS