Published October 1988 | Version v1
Journal article Metadata-only

The synthesis of tritium-labelled azidothymidine

Creators

  • 1. Tulane Univ., New Orleans, LA (USA). School of Medicine

Description

The synthesis of 3H-labelled azidothymidine (AZT) from [methyl-3H]thymidine is described. Purification of labelled AZT was accomplished by column chromatography. The purity of the labelled compound was determined by high performance liquid chromatography connected with a radioactive flow detector. The labelled AZT was found to be stable at pH ranging from 2.3 to 7.4 at 370C and at hyperthermic temperature of 420C. (author)

Additional details

Publishing Information

Journal Title
Journal of Labelled Compounds and Radiopharmaceuticals
Journal Volume
25
Journal Issue
10
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1055-1060
ISSN
0362-4803
CODEN
JLCRD

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
20032587
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Descriptors DEI
AIDS; AZIDO COMPOUNDS; CHEMICAL PREPARATION; LABELLING; RADIOPHARMACEUTICALS; THYMIDINE; TRITIUM COMPOUNDS
Descriptors DEC
AZINES; DISEASES; DRUGS; HEMIC DISEASES; HETEROCYCLIC COMPOUNDS; HYDROGEN COMPOUNDS; INFECTIOUS DISEASES; LABELLED COMPOUNDS; MATERIALS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIOACTIVE MATERIALS; RIBOSIDES; SYNTHESIS; VIRAL DISEASES

Optional Information

Contract/Grant/Project number
Grant AI25909