Radioactive iodine labeled phenolic amines
Creators
Description
The invention is accomplished by the formation at the site of use of the radioactive amine of the invention which is then injected immediately into the mammal for diagnostic purposes. The compounds of the invention are as follows: 1-HO,2-(R1-N(-R2)-(H2C)N-N(-R3)-H2C-);4-I,6-R4-BENZENE In the above compound, R1, R2, R3 and R4 are independently any straight or branched alkyl of between 1 and about 10 carbons; n may be between 1 and about 20. In the invention, the radio labeling of the invention compound is accomplished immediately prior to use of the radio labeled material. The compounds of the invention when boiled for about 15 minutes with iodine-123, a radioactive material, undergo a substitution of radioactive for non-radioactive iodine such that the compound becomes labeled and suitable for use. The compound itself, prior to radio labeling, is storage stable
Availability note (English)
U.S. Commissioner of Patents, Washington, D.C. 20231, USA, $.50.Additional details
Publishing Information
- Imprint Pagination
- v p.
- IPC:
- Int. Cl. A61K 43/00; A61K 49/00.
- IPC
- Int. Cl. A61K 43/00; A61K 49/00.
- Patent number
- US patent document 4,430,319/A/
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 16006560
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE; S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Resource subtype / Literary indicator
- Non-conventional Literature
- Descriptors DEI
- AMINES; AROMATICS; CHEMICAL PREPARATION; IODINE 123; LABELLING; ORGANIC IODINE COMPOUNDS; PH VALUE; PHENOLS; RADIOPHARMACEUTICALS; UPTAKE
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS
Optional Information
- Notes
- PAT-APPL-380720.