Published February 1999
| Version v1
Journal article
Mild synthesis of [N-methyl-11C]-isovaleroyl-(L)-carnitine. The usefulness of a tritium approach
Creators
- 1. Istituto di Chimica Nucleare - C.N.R., C.P. 10, Rome (Italy)
- 2. Istituto di Chimica Nucleare -- C.N.R., C.P. 10 -- 00016 Monterotondo Stazione, Roma, (Italy)
- 3. Istituto di Neuroscienze e Bioimmagini - C.N.R., H.S. Raffaele, Milan (Italy)
- 4. Sigma-Tau, Industrie Farmaceutiche Riunite S.p.A., Pomezia, Rome (Italy)
Description
The title carnitine derivative was labelled both with [11C]methyl iodide and [3H]methyl iodide. The former was synthesized in order to improve the knowledge of the acyl carnitines fate in humans. The latter was synthesized, at approximately the same concentration level as that of the former, in order to optimize its radiosynthesis, taking advantage from the long half-life of the tritium
Additional details
Identifiers
- PII
- S096980439710135X;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 50
- Journal Issue
- 2
- Journal Page Range
- p. 303-309
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 34015078
- Subject category
- S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
- Descriptors DEI
- CARBON 11; CARNITINE; LABELLING; METHYL IODIDE; SYNTHESIS; TRITIUM COMPOUNDS
- Descriptors DEC
- AMINO ACIDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CARBON ISOTOPES; CARBOXYLIC ACIDS; EVEN-ODD NUCLEI; HALOGENATED ALIPHATIC HYDROCARBONS; HYDROGEN COMPOUNDS; HYDROXY ACIDS; IODINATED ALIPHATIC HYDROCARBONS; ISOTOPES; LIGHT NUCLEI; MINUTES LIVING RADIOISOTOPES; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; RADIOISOTOPES; VITAMIN B GROUP; VITAMINS
Optional Information
- Copyright
- Copyright (c) 1999 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.