Children after Chernobyl: immune cells adaptive changes and stable alterations under low-dose irradiation
- 1. Laboratory of Immunocytology, Dept. of Clinical Immunology, Dept. of Pediatric Hematology, Inst. of Clinical Radiology, Research Centre for Radiation Medicine, Kiev (Ukraine)
Description
Early changes of immune parameters in children evacuated from 30-km zone were characterized by E-rossette forming cells decrease and E-receptor non-stability in theophylline assay, surface Ig changes. Immunological follow-up of children inhabitants of territories contaminated with radionuclides after Chernobyl accident revealed TCR/CD3, CD4 and MHC CD3+, CD4+, CD57+ subsets, RIL-2, TrT expression and calcium channel activity. PMNC percentage with cortical thymocyte phenotype (CD1+, CD4+8+) was elevated during the first years after the accident and seemed to be of a compensatory origin. Combination of heterogenic activation and suppression subset reactions and changes in fine subset (Th1/Th2) organization were suggested. Adaptive and compensatory reactions were supposed and delayed hypersensitivity reactions increase as well. (author)
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Additional details
Publishing Information
- Imprint Title
- Low doses of ionizing radiation: Biological effects and regulatory control. Contributed papers
- Imprint Pagination
- 696 p.
- Journal Page Range
- p. 67-70.
- ISSN
- 1011-4289
- Report number
- IAEA-TECDOC--976
Conference
- Title
- Biological effects and regulatory control.
- Acronym
- International conference on low doses of ionizing radiation
- Dates
- 17-21 Nov 1997.
- Place
- Seville (Spain).
INIS
- Country of Publication
- International Atomic Energy Agency (IAEA)
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 29017298
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; S61: RADIATION PROTECTION AND DOSIMETRY;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- ANTIBODIES; BIOLOGICAL RADIATION EFFECTS; CHERNOBYLSK-4 REACTOR; CHILDREN; IMMUNITY; IMMUNOLOGY; PUBLIC HEALTH; RADIATION DOSES; REACTOR ACCIDENTS; UKRAINE
- Descriptors DEC
- ACCIDENTS; ANIMALS; BIOLOGICAL EFFECTS; EASTERN EUROPE; ENRICHED URANIUM REACTORS; EUROPE; GRAPHITE MODERATED REACTORS; LWGR TYPE REACTORS; MAMMALS; MAN; MEDICINE; POWER REACTORS; PREVENTIVE MEDICINE; PRIMATES; RADIATION EFFECTS; REACTORS; THERMAL REACTORS; VERTEBRATES; WATER COOLED REACTORS
Optional Information
- Notes
- 10 refs.
- Secondary number(s)
- IAEA-CN--67/16.