Published February 9, 1987
| Version v1
Journal article
NMR study of the interaction of P-450 with 4-methoxypyridine
- 1. Academy of Sciences of the USSR, Novosibirsk. Inst. of Clinical and Experimental Medicine
- 2. AN SSSR, Novosibirsk. Inst. Khimicheskoj Kinetiki i Goreniya
Description
Longitudinal relaxation (T1) measurements for all lines (α-CH, β-CH, O-CH3) in the 4-methoxypyridine 1H-NMR spectrum were used to study the interaction of 4-methoxypyridine with purified microsomal cytochrome P-450 from livers of phenobarbital-treated rats. The paramagnetic contribution to the observed T1-1 value was determined from its dependence on 4-methoxypyridine concentration. In the P-450-4-methoxypyridine complex the latter is oriented so that the nitrogen of pyridine is directed towards the Fe3+. (Auth.)
Additional details
Publishing Information
- Journal Title
- FEBS (Fed. Eur. Biochem. Soc.) Lett.
- Journal Volume
- 212
- Journal Issue
- 1
- Series
- FEBS (Fed. Eur. Biochem. Soc.) Lett.
- Journal Page Range
- 53-57
- ISSN
- 0014-5793
- CODEN
- FEBLA
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 18056371
- Subject category
- S60: APPLIED LIFE SCIENCES;
- Descriptors DEI
- COMPLEXES; CYTOCHROMES; MOLECULAR STRUCTURE; NMR SPECTRA; NUCLEAR MAGNETIC RESONANCE; PROTONS; PYRIDINES; SUBSTRATES
- Descriptors DEC
- AZINES; BARYONS; CATIONS; CHARGED PARTICLES; ELEMENTARY PARTICLES; FERMIONS; HADRONS; HETEROCYCLIC COMPOUNDS; HYDROGEN IONS; HYDROGEN IONS 1 PLUS; IONS; MAGNETIC RESONANCE; NUCLEONS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PIGMENTS; RESONANCE; SPECTRA
Optional Information
- Notes
- 18 refs.; 3 figs.; 2 tabs.