Molecular and functional properties of the granulocyte specific MAb BW 250/183 suited for the immunoscintigraphic localization of inflammatory processes

The molecular characteristics of MAb BW 250/183 like high affinity and specificity for granulocytes and high epitope density on the granulocyte membrane are optimal prerequisites for in vivo binding to human granulocytes. The lack of negative, i.e. stimulatory influences on granulocyte associated physiological functions should not result in any side effects during diagnostic application. Combined with the recently developed 99mTc labelling procedure the MAb BW 250/183-99mTc conjugate is a safe, reliable and easy to handle reagent for the successful localization of inflammatory processes. (orig.)