One-Pot Conversion and Separation of Methyl Eugenol by Vacuum Fractionation

The conversion and direct separation of methyl eugenol (ME) in one-pot fractionation vacuum is presented. Mixtures containing eugenol (Eu), sodium hydroxide (NaOH) and dimethyl sulphate (DMS) as methylation agent were reacted in pot of fractionation vacuum. After finished methylation, the mixture direct separation in same pot of fractionation vacuum. The parameter process is observed ratio Eu to DMS, time reaction and temperatures. The best results is obtained 1:3 of the ratio Eu to DMS, 6 hour of time reaction and 100oC of temperatures. Concentration methyl eugenol after separation gave 98.06%. The one-pot fractionation is good conversion directly separation to obtain ME from Eu of clove oil with high concentration and efficient process. (paper)