1, 3-dipolar cycloaddition as a general route for functionalization of Fe3O4 nanoparticles

Triazole formation by 1, 3-dipolar cycloaddition reactions has been used to functionalize the surface of Fe3O4 nanoparticles. Fe3O4 particle samples with diameters around 22 nm were synthesized without any additional stabilizer, and were then treated with silane coupling agent to react with propargyl acid. The alkynyl group on the Fe3O4 surface provides better conjugation efficiency with azide derivative molecules, which led to their attachment through the formation of a 1, 2, 3-triazole ring