Published 1988
| Version v1
Book
Serial MRI studies using gadolinium DTPA in active multiple sclerosis
- 1. National Hospital for Nervous Diseases, London (UK). Lysholm Radiological Dept.
Description
It has been suggested that blood brain barrier (BBB) impairment is a necessary early event in the pathogenesis of the multiple sclerosis (MS) lesions. To evaluate such an hypothesis in vivo would require: (1) serial imaging studies using a modality with high sensitivity for detecting plaques; (2) a contrast enhancing agent which demonstrates BBB impairment. A serial magnetic resonance imaging (MRI) study was undertaken of a group of MS patients using the contrast agent gadolinium-DTPA. As it has been suggested that T1 and T2 relaxation times are longer in acute than chronic MS lesions, these were also measured. 3 refs.; 1 figure
Additional details
Publishing Information
- Publisher
- Excerpta Medica.
- Imprint Place
- Amsterdam (Netherlands)
- Imprint Title
- Trends in European multiple sclerosis research
- Imprint Pagination
- 444 p.
- Journal Issue
- no. 772
- Series
- International Congress Series.
- Journal Page Range
- p. 279-281.
Conference
- Title
- European committee for treatment and research in multiple sclerosis (ECTRIMS) congress.
- Dates
- 3-5 Sep 1987.
- Place
- Lyon (France).
INIS
- Country of Publication
- Netherlands
- Country of Input or Organization
- Netherlands
- INIS RN
- 20026555
- Subject category
- S62: RADIOLOGY AND NUCLEAR MEDICINE;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- BLOOD; BRAIN; DTPA; GADOLINIUM COMPOUNDS; NERVOUS SYSTEM DISEASES; NMR IMAGING; PERMEABILITY; SPIN-LATTICE RELAXATION; SPIN-SPIN RELAXATION
- Descriptors DEC
- AMINO ACIDS; BIOLOGICAL MATERIALS; BODY; BODY FLUIDS; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHELATING AGENTS; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; MATERIALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIOPROTECTIVE SUBSTANCES; RARE EARTH COMPOUNDS; RELAXATION; RESPONSE MODIFYING FACTORS
Optional Information
- Notes
- Imprint:Contains index of authors.