Published October 23, 2013 | Version v1
Journal article Metadata-only

MicroRNA in Human Glioma

Creators

  • 1. Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)
  • 2. Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, Guangzhou 510080 (China)
  • 3. Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)
  • 4. Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080 (China)
  • 5. Key Laboratory of Functional Molecules from Oceanic Microorganisms (Sun Yat-sen University), Department of Education of Guangdong Province, Guangzhou 510080 (China)

Description

Glioma represents a serious health problem worldwide. Despite advances in surgery, radiotherapy, chemotherapy, and targeting therapy, the disease remains one of the most lethal malignancies in humans, and new approaches to improvement of the efficacy of anti-glioma treatments are urgently needed. Thus, new therapeutic targets and tools should be developed based on a better understanding of the molecular pathogenesis of glioma. In this context, microRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in the development of the malignant phenotype of glioma cells, including cell survival, proliferation, differentiation, tumor angiogenesis, and stem cell generation. This review will discuss the biological functions of miRNAs in human glioma and their implications in improving clinical diagnosis, prediction of prognosis, and anti-glioma therapy

Availability note (English)

Available from http://dx.doi.org/10.3390/cancers5041306; Available from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875941

Additional details

Identifiers

URL
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875941;
DOI
10.3390/cancers5041306;

Publishing Information

Journal Title
Cancers (Basel)
Journal Volume
5
Journal Issue
4
Journal Page Range
p. 1306-1331
ISSN
2072-6694

INIS

Country of Publication
Switzerland
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
47001936
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
AMPLIFIERS; BIOLOGICAL FUNCTIONS; BIOLOGICAL MARKERS; FILLERS; FORECASTING; GLIOMAS; STEM CELLS; THERAPY
Descriptors DEC
ANIMAL CELLS; DISEASES; ELECTRONIC EQUIPMENT; EQUIPMENT; MEDICINE; NEOPLASMS; NERVOUS SYSTEM DISEASES; SOMATIC CELLS

Optional Information

Copyright
Copyright (c) 2013 by the authors
Notes
PMCID: PMC3875941; PMID: 24202447; PUBLISHER-ID: cancers-05-01306; OAI: oai:pubmedcentral.nih.gov:3875941; licensee MDPI, Basel, Switzerland.; This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).