Published September 2021 | Version v1
Journal article Metadata-only

Stereotactic radiosurgery for brain metastases from small cell lung cancer without prior whole-brain radiotherapy: A meta-analysis

Creators

  • 1. Ribeirão Preto Medical School, Department of Medical Imagings, Hematology and Oncology of University of São Paulo (FMRP-USP) (Brazil)
  • 2. Radiation Oncology Department - Americas Centro de Oncologia Integrado, Rio de Janeiro (Brazil)
  • 3. Sunnybrook Health Sciences Centre, Toronto (Canada)
  • 4. Department of Oncology - Division of Radiation Oncology, Kingston General Hospital, Queen's University, Kingston (Canada)

Description

Highlights: • Stereotactic radiosurgery (SRS) as an upfront treatment for small cell lung cancer (SCLC) is controversial. • The meta-analysis showed a favorable outcome for local control and overall survival in high selected patients with SRS. • The salvage treatment of distant brain failures resulted in a reduced risk of neurological death. • These findings support the design of future randomized clinical trials. Assess upfront Stereotactic radiosurgery (SRS) effectiveness for small cell lung cancer (SCLC) brain metastases (BM). Where possible, a comparison with whole-brain radiotherapy (WBRT) was performed.

Availability note (English)

Available from http://dx.doi.org/10.1016/j.radonc.2021.06.026

Additional details

Identifiers

DOI
10.1016/j.radonc.2021.06.026;
PII
S0167814021066093;

Publishing Information

Journal Title
Radiotherapy and Oncology
Journal Volume
162
Journal Page Range
p. 45-51
ISSN
0167-8140
CODEN
RAONDT

INIS

Country of Publication
Netherlands
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
54014099
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; CLINICAL TRIALS; DEATH; FAILURES; LUNGS; METASTASES; NEOPLASMS; PATIENTS; RADIOTHERAPY; SURGERY
Descriptors DEC
BODY; CENTRAL NERVOUS SYSTEM; DISEASES; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; TESTING; THERAPY

Optional Information

Copyright
Copyright (c) 2021 Elsevier B.V. All rights reserved.