Published August 2003 | Version v1
Journal article Metadata-only

18F-FDG PET study after bilateral capsulotomy in obsessive-compulsive disorder

Creators

  • 1. Fudan Univ., Shanghai (China). Huashan Hospital, PET Center and Nuclear Medicine Department

Description

Objective: To assess the changes in regional glucose metabolism following bilateral capsulotomy in patients with medically intractable obsessive-compulsive disorder (OCD). Methods: Eight OCD patients underwent bilateral anterior capsulotomy. 18F-fluorodeoxyglucose (FDG) PET data obtained before and after operation were subjected to statistical parameter mapping (SPM) . Results: The glucose metabolism decrease was found in the left cingulategyrus, caudatum, left and right thalamic nucleus medialis dorsalis nuclei, bilateral medial and inferior frontal white matter. Conclusion: SPM analysis showed the significant change of cingulate-striatum-thalamic circuits in OCD patients after operation, and the findings implicate that the decreased cerebral metabolism in cingulate gyrus, striatum, and thalamus could be related to bilateral capsulotomy which blocks the abnormal functional connection of corticolimbic loop

Additional details

Publishing Information

Journal Title
Chinese Journal of Nuclear Medicine
Journal Volume
23
Journal Issue
4
Journal Page Range
p. 222-223
ISSN
0253-9780

INIS

Country of Publication
China
Country of Input or Organization
China
INIS RN
36021318
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BEHAVIOR; BIOMEDICAL RADIOGRAPHY; BRAIN; CENTRAL NERVOUS SYSTEM; DEOXYRIBOSE; FLUORINE 18; GLUCOSE; IMAGE PROCESSING; IMAGES; INTRAVENOUS INJECTION; LABELLED COMPOUNDS; MENTAL DISORDERS; METABOLISM; NERVOUS SYSTEM DISEASES; PATHOLOGY; POSITRON COMPUTED TOMOGRAPHY; SURGERY
Descriptors DEC
ALDEHYDES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CARBOHYDRATES; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HEXOSES; HOURS LIVING RADIOISOTOPES; INJECTION; INTAKE; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MEDICINE; MONOSACCHARIDES; NANOSECONDS LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEAR MEDICINE; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; PENTOSES; PROCESSING; RADIOISOTOPES; RADIOLOGY; SACCHARIDES; TOMOGRAPHY