The theory of individual variability of osteotropic radionuclides metabolism

The aim of this paper is to study mechanisms of individual peculiarities of osteotropic radionuclides skeletal metabolism, and to develop approach for dose value prediction. Some regulations explaining the importance of skeleton in radionuclides metabolism and showing the direction of search of its quantitative regularities are taken as a basis of these theory. The first, there are three evolution treads: universal significance of calcium in the cells in the row beginning from bacteria to highest organizms and increase of its regulator role in the multicellular on the level of organizm; ability of calcium salts to increase mechanical strength of supporting tissues; growing connection of metabolic and supporting function. The second, bone is involved in metabolism of radionuclides as a structurally functional wholeness. The third metabolic way of radionuclide from blood into bone consists of a number of stages. (author)