Published January 2008 | Version v1
Journal article Metadata-only

Synthesis, radiolabeling and baboon SPECT imaging of 2β-carbomethoxy-3β-(3'-[123I]iodophenyl)tropane ([123I]YP256) as a serotonin transporter radiotracer

Creators

  • 1. Yale University, School of Medicine, VA Connecticut HCS (116A2), West Haven, CT 06516 (United States)
  • 2. Department of Psychiatry and Neuroscience Program, Harvard Medical School, Mailman Research Center McLean Division of Massachusetts General Hospital, Belmont, MA 02478 (United States)
  • 3. Institute for Neurodegenerative Disorders, New Haven, CT 06510 (United States)

Description

To develop a potential SPECT probe to evaluate the integrity of the serotoninergic system (5-HTT) whose dysfunction is linked to several disease conditions such as Parkinson's disease, Alzheimer's disease and depression, we report the synthesis, radiolabeling and in vivo baboon imaging of 2β-carbomethoxy-3β-(3'-[123I]iodophenyl) tropane (YP256, ). The radiolabeling was performed by iododestannylation using sodium [123I]iodide and peracetic acid. Although the ligand displayed high selectivity for 5-HTT over dopamine transporter in vitro, SPECT imaging in baboons did not reveal selective 5-HTT accumulation in brain in vivo

Availability note (English)

Available from http://dx.doi.org/10.1016/j.nucmedbio.2007.09.002

Additional details

Identifiers

DOI
10.1016/j.nucmedbio.2007.09.002;
PII
S0969-8051(07)00240-5;

Publishing Information

Journal Title
Nuclear Medicine and Biology
Journal Volume
35
Journal Issue
1
Journal Page Range
p. 53-59
ISSN
0969-8051
CODEN
NMBIEO

INIS

Country of Publication
United Kingdom
Country of Input or Organization
International Atomic Energy Agency (IAEA)
INIS RN
39048516
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BABOONS; BRAIN; DOPAMINE; IN VITRO; IN VIVO; IODIDES; IODINE 123; LABELLING; LIGANDS; NERVOUS SYSTEM DISEASES; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; SEROTONIN; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; SYNTHESIS; TRACER TECHNIQUES
Descriptors DEC
AMINES; ANIMALS; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; AZAARENES; AZOLES; BETA DECAY RADIOISOTOPES; BODY; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HALIDES; HALOGEN COMPOUNDS; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INDOLES; INTERMEDIATE MASS NUCLEI; IODINE COMPOUNDS; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KINETICS; LABELLED COMPOUNDS; MAMMALS; MATERIALS; MONKEYS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; PRIMATES; PYRROLES; RADIOACTIVE MATERIALS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; SYMPATHOMIMETICS; TOMOGRAPHY; TRYPTAMINES; VERTEBRATES

Optional Information

Copyright
Copyright (c) 2008 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.