Published February 1979
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Strain differences in the embryotoxicity of 239Pu
Creators
Description
Differences in prenatal response in three strains of rats (Sprague-Dawley, Wistar, Fischer) were compared following intravenous administration of monomeric 239Pu at 9 days of gestation (dg). Dose-dependent embryolethality, 239Pu concentrations in the fetoplacental unit, and fetal hematologic status were evaluated. Embryomortality was lowest in the Wistar strain at all dose levels, as was the 239Pu concentration of the fetoplacental unit. Plutonium-239 was localized in the visceral yolk sac of all three rat strains. Effects on hematologic status were observed at 20 days gestation in Fischer but not in Wistar fetuses
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Additional details
Additional titles
- Augmented title (English)
- Rats
Publishing Information
- Imprint Title
- Pacific Northwest Laboratory annual report for 1978 to the DOE Assistant Secretary for Environment. Part 1. Biomedical sciences
- Journal Page Range
- p. 3.77-3.80.
- Report number
- PNL--2850(Pt.1)
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 10473056
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Numerical Data
- Descriptors DEI
- BIOLOGICAL LOCALIZATION; BIOLOGICAL VARIABILITY; DOSE-RESPONSE RELATIONSHIPS; EMBRYOS; EXPERIMENTAL DATA; GRAPHS; HEMATOLOGY; ISOLATED VALUES; MORTALITY; PLACENTA; PLUTONIUM 239; PREGNANCY; RATS; TOXICITY
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; DATA; DATA FORMS; EVEN-ODD NUCLEI; FETAL MEMBRANES; HEAVY NUCLEI; INFORMATION; ISOTOPES; MAMMALS; MEDICINE; MEMBRANES; NUCLEI; NUMERICAL DATA; PLUTONIUM ISOTOPES; RADIOISOTOPES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES