Published April 2011
| Version v1
Journal article
Questioning the value of 99mTc-HYNIC-annexin V based response monitoring after docetaxel treatment in a mouse model for hereditary breast cancer
Creators
- 1. Division of Diagnostic Oncology, Netherland Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), Plesmanlaan 121, 1066CX Amsterdam (Netherlands)
- 2. Division of Radiotherapy, Netherland Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), Plesmanlaan 121, 1066CX Amsterdam (Netherlands)
- 3. Division of Molecular Biology, Netherland Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), Plesmanlaan 121, 1066CX Amsterdam (Netherlands)
Description
Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of 99mTc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in 99mTc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, 99mTc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.
Availability note (English)
Available from http://dx.doi.org/10.1016/j.apradiso.2010.12.012Additional details
Identifiers
- DOI
- 10.1016/j.apradiso.2010.12.012;
- PII
- S0969-8043(10)00489-6;
Publishing Information
- Journal Title
- Applied Radiation and Isotopes
- Journal Volume
- 69
- Journal Issue
- 4
- Journal Page Range
- p. 656-662
- ISSN
- 0969-8043
- CODEN
- ARISEF
INIS
- Country of Publication
- United Kingdom
- Country of Input or Organization
- International Atomic Energy Agency (IAEA)
- INIS RN
- 42077094
- Subject category
- S07: ISOTOPES AND RADIATION SOURCES;
- Descriptors DEI
- ACCURACY; APOPTOSIS; MAMMARY GLANDS; NEOPLASMS; RADIOPHARMACEUTICALS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TECHNETIUM 99
- Descriptors DEC
- BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; GLANDS; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MATERIALS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOACTIVE MATERIALS; RADIOISOTOPES; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES
Optional Information
- Copyright
- Copyright (c) 2010 Elsevier Science B.V., Amsterdam, The Netherlands, All rights reserved.