Study of inhaled radio-active pollutants: 1. Current data; II. Pathology; III. Validity of animal model. Dose-effect relations
Creators
- 1. CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Section de Pathologie et Toxicologie Experimentale
- 2. CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Dept. de Protection
- 3. Association Euratom-CEA, Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Niveaux de Contamination Radioactive du Milieu Ambiant et de la Chaine Alimentaire
- 4. CEA, 87 - Razes (France). Div. Miniere de la Crouzille
- 5. Centre Hospitalier Universitaire, 94 - Creteil (France)
Description
An attempt has been made to develop an animal for human industrial exposure to airradiation. That will give results applicable to man both qualitatively and quantitavely. Using over 2000 animals. The following studies were made. Radon, rat and occupationally exposed man; 239 plutonium oxide, rat and monkey; 12 different α and emitters, rat with different exposure media (aerosols particles) and exposure shcedules (acute chronic). Scrupulous pathological, microscopic, autoradiographic and ultrastructural analysis of animals followed their deaths. Acute changes are characterized by alveolaroedema, capillary and arteriolar thrombisus, and desquamation of type 1 pneumatocytes. There is interstitial pneumonia, hyaline membrane formation, and extensive bronchiolar and alveolar metaplasia. In a study of long-term effects a wide variety of both benign and malignant tumours was discovered. There are variations in species lateney and radiation sensitivity. The pathological changes, found in these studies are qualitatively very similar to changes found in man
Abstract (French)
On a realise des experiences sur l'animal pour etudier les effets sur l'homme de l'exposition aux rayonnements en milieu industriel. On a obtenu des resultats applicables a l'homme a la fois qualitativement et quantitativement. On a utilise plus de 2000 animaux. Les etudes suivantes ont ete realisees: avec le radon - rat et homme professionnellement expose; avec l'oxyde de plutonium 239 - rat et singe; effets sur le rat d'une dizaine d'emetteurs α. La mort des animaux est suivie d'une etude microscopique, autoradiographique et ultrastructurale. Les lesions precoces se traduisent par un oedeme alveolaire, par des thromboses capillaires ou arteriolaires, une desquamation des pneumocytes I. Il y a une pneumonie interstitielle a membranes hyalines, apparition de foyers de metaplasies dans les bronchioles et les alveoles. Dans une etude des effets a long terme, une grande variete de tumeurs benignes et malignes a ete trouvee. Les modifications pathologiques rencontrees dans ces etudes sont qualitativement semblables a celles rencontrees chez l'hommeAdditional details
Additional titles
- Original title (French)
- Etude experimentale des polluants radio-actifs inhales: I. Donnees actuelles; II. Inventaire lesionnel; III. Validite du modele animal. Relations dose-effet
Publishing Information
- Publisher
- Institut National de la Sante et de la Recherche Medicale.
- Imprint Place
- Paris, France
- Imprint Title
- Broncho-pulmonary reactions to airborne pollutants
- Imprint Pagination
- p. 307-324.
Conference
- Title
- Colloquium on broncho-pulmonary reactions to airborne pollutants.
- Dates
- 18 Jan 1974.
- Place
- Pont-a-Mousson, France.
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 6213051
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Resource subtype / Literary indicator
- Conference
- Descriptors DEI
- DELAYED RADIATION EFFECTS; DOSE-RESPONSE RELATIONSHIPS; EARLY RADIATION EFFECTS; INHALATION; LUNGS; MONKEYS; NEOPLASMS; PLUTONIUM 239; PNEUMONIA; RADON; RATS
- Descriptors DEC
- ACTINIDE NUCLEI; ALPHA DECAY RADIOISOTOPES; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DISEASES; ELEMENTS; EVEN-ODD NUCLEI; HEAVY NUCLEI; INTAKE; ISOTOPES; MAMMALS; NONMETALS; NUCLEI; ORGANS; PLUTONIUM ISOTOPES; PRIMATES; RADIATION EFFECTS; RADIOISOTOPES; RARE GASES; RESPIRATORY SYSTEM; RESPIRATORY SYSTEM DISEASES; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES
Optional Information
- Notes
- Imprint:Reactions bronchopulmonaires aux polluants atmospheriques.;Compte rendu du colloque. Pont-a-Mousson, France, 18-19 janvier 1974.