Influence of neoadjuvant radiation therapy by large dose fractionation on distant results of multimodality therapy for breast cancer

The article presents a retrospective analysis of the neoadjuvant radiotherapy in large fractions mode to remote results of treatment of patients with breast cancer. Long-term results of the effectiveness of the treatment were assessed in terms of the three-year disease-free survival. Found that the performance of patients included in the study lived longer without recurrence after preoperative radiotherapy in large fractions mode than after adjuvant radiotherapy by classic fractionation. It is proved that the survival of breast cancer patients stage II after preoperative radiotherapy in large fractions mode higher than after only adjuvant radiotherapy. Concluded that the method of choice for the treatment of patients with breast cancer is stage II is neoadjuvant radiotherapy mode large fractions followed by radical surgery