Published September 1982
| Version v1
Journal article
Synthesis and radioprotective activity of germa and silathiazolidines
Creators
- 1. Universite Paul Sabatier, 31 - Toulouse (France)
- 2. Centre de Recherche du Service de Sante des Armees, Clamart (France)
- 3. Direction des Recherches Etudes et Techniques, 75 - Paris (France)
- 4. Institut deTopologie et de Dynamique des Systemes de l'Universite de Paris VII, 75 - Paris (France)
Description
Synthesis of many isologues from the IVb series of thiazolidines has been carried out by replacing the carbon atom in the 2 position by a germanium or a silicon atom. These compounds have generally a higher radioprotective activity with a DRF greater than those of cysteamine and also a higher toxicity in the case of germanium derivatives
Abstract (French)
Trente-deux germa- et silathiazolidines ont ete synthetisees. Leur activite radioprotectrice est generalement superieure a celle de leurs isologues carbones. La toxicite des derives silicies est comparable a celle des derives carbones; celle des derives germanies est en general plus eleveeAdditional details
Additional titles
- Original title (French)
- Synthese et activite radioprotectrice de germa- et silathiazolidines
Publishing Information
- Journal Title
- Eur. J. Med. Chem. - Chim. Ther.
- Journal Volume
- 17
- Journal Issue
- 5
- Series
- Eur. J. Med. Chem. - Chim. Ther.
- Journal Page Range
- 433-436
INIS
- Country of Publication
- France
- Country of Input or Organization
- France
- INIS RN
- 14741794
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- RADIOPROTECTIVE SUBSTANCES; SYNTHESIS; THIAZOLES; TOXICITY
- Descriptors DEC
- AZOLES; DRUGS; HETEROCYCLIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; RESPONSE MODIFYING FACTORS