DNA repair in gamma-and UV-irradiated Escherichia coli treated with caffeine and acriflavine
Description
A study is made of the postradiation effect of caffeine and acriflavine on the survival rate and DNA repair in E. coli exposed to γ- and UV-radiation. When added to postradiation growth medium caffeine and acriflavine lower the survival rate of γ-irradiated radioresistant strains, B/r and Bsub(s-1)γR, and UV-irradiated UV-resistant strain B/r, and do not appreciably influence the survival of strains that are sensitive to γ- and UV-radiation. The survival rate of UV-irradiated mutant BsUb(s-1) somewhat increases in the presence of caffeine. Caffeine and acriflavine inhibit repair of single-stranded DNA breaks induced in strain B/r by γ-radiation (slow repair) and UV light. Acriflavine arrests a recombination branch of postreplication repair of DNA in E. coli Bsub(s-1)γR Whereas caffeine does not influence this process
Additional details
Additional titles
- Original title (Russian)
- Репарация ДНК в γ- и УФ-облученных клетках Escherichia coli при действии кофеина и акрифлавина
Publishing Information
- Journal Title
- Radiobiologiya
- Journal Volume
- 18
- Journal Issue
- 6
- Series
- Radiobiologiya.
- Journal Page Range
- 829-835
INIS
- Country of Publication
- USSR
- Country of Input or Organization
- USSR
- INIS RN
- 10484493
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ACRIFLAVINE; BIOLOGICAL REPAIR; CAFFEINE; DNA; ESCHERICHIA COLI; GAMMA RADIATION; GENETIC RADIATION EFFECTS; SURVIVAL CURVES; ULTRAVIOLET RADIATION
- Descriptors DEC
- ACRIDINES; AMINES; AZINES; BACTERIA; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; DRUGS; ELECTROMAGNETIC RADIATION; FLAVINES; GENETIC EFFECTS; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; MICROORGANISMS; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PURINES; PYRIDINES; RADIATION EFFECTS; RADIATIONS; XANTHINES
Optional Information
- Notes
- For English translation see the journal Radiobiology.