Published 1979
| Version v1
Journal article
Response of clonogenic cells of mice solid tumour NKLy/LL to N-methyl-N-nitrosourea
Creators
- 1. AN SSSR, Moscow. Inst. Khimicheskoj Fiziki
Description
By cloning in vitro the cells of NKLy/LL solid tumour of mice it has been shown that the curve of clonogenic cell survival versus N-methyl-N-nitrosourea (MNU) dose in the 12.5-200.0 mg/kg interval is exponential and characterized by Dsub(o)=29.15 mg/kg dose value. Large size tumours (15.0-17.0 g) are characterized by higher death rate of clonogenic cells (survivor fraction approximately 0.5%) than in 1.0-7.0 g tumours (survivor fraction 2-4%). That is, evidently, related to higher sensitivity of the resting tumour cells to MNU
Additional details
Additional titles
- Original title (Russian)
- Реакция клоногенных клеток солидной опухоли NKLy/LL мышей на Н-метил-Н-нитрозомочевину
Publishing Information
- Journal Title
- Vopr. Onkol.
- Journal Volume
- 25
- Journal Issue
- 5
- Series
- Vopr. Onkol.
- Journal Page Range
- 43-47
- ISSN
- 0507-3758
INIS
- Country of Publication
- Russian Federation
- Country of Input or Organization
- USSR
- INIS RN
- 11531130
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- ANIMAL CELLS; CARBONIC ACID DERIVATIVES; CHEMOTHERAPY; CLONE CELLS; DOSE-RESPONSE RELATIONSHIPS; INTRAPERITONEAL INJECTION; LABELLED COMPOUNDS; MICE; NEOPLASMS; ORGANIC NITROGEN COMPOUNDS; SURVIVAL CURVES; THYMIDINE
- Descriptors DEC
- ANIMALS; AZINES; CELL CULTURES; DISEASES; HETEROCYCLIC COMPOUNDS; INJECTION; INTAKE; MAMMALS; MEDICINE; NUCLEOSIDES; NUCLEOTIDES; ORGANIC COMPOUNDS; PYRIMIDINES; RIBOSIDES; RODENTS; THERAPY; VERTEBRATES