Published May 28, 2018 | Version v1
Journal article Metadata-only

Rapid aqueous late-stage radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange. Towards new PET imaging probes

Creators

  • 1. School of Chemistry, University of Southampton (United Kingdom)
  • 2. GE Healthcare, The Grove Centre, Amersham (United Kingdom)

Description

A simple and rapid method for 18F radiolabelling of [GaF3(BnMe2-tacn)] by 18F/19F isotopic exchange is described. The use of MeCN/H2O or EtOH/H2O (75:25) and aqueous [18F]F- (up to 200 MBq) with heating (80 C, 10 min) gave 66±4 % 18F incorporation at a concentration of 268 nm, and 37±5 % 18F incorporation at even lower concentration (27 nm), without the need for a Lewis acid promoter. A solid-phase extraction method was established to give [Ga18F19F2(BnMe2-tacn)] in 99 % radiochemical purity in an EtOH/H2O mixture. (copyright 2018 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Availability note (English)

Available from: http://dx.doi.org/10.1002/anie.201802446

Additional details

Identifiers

DOI
10.1002/anie.201802446;

Publishing Information

Journal Title
Angewandte Chemie (International Edition)
Journal Volume
57
Journal Issue
22
Journal Page Range
p. 6658-6661
ISSN
1433-7851
CODEN
ACIEF5

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
49060298
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY; S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
FLUORINATION; FLUORINE 18; FLUORINE 19; GALLIUM COMPOUNDS; ISOTOPIC EXCHANGE; LABELLING; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS
Descriptors DEC
BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; CHEMICAL REACTIONS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HALOGENATION; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NANOSECONDS LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; STABLE ISOTOPES; TOMOGRAPHY

Optional Information

Notes
With 2 figs., 1 tab., 23 refs.