Published December 1977 | Version v1
Journal article Metadata-only

Ataxia telangiectasia: the effects of chemical mutagens and x-rays on sister chromatid exchanges in blood lymphocytes

Creators

  • 1. Western General Hospital, Edinburgh (UK)

Description

It is now possible to examine in detail exchanges between sister chromatids (SCEs) and to attempt to investigate the relationships of such exchanges to aberration formation and DNA-repair mechanisms. The frequency of SCEs is dramatically increased by chemical mutagens and may reflect the level of DNA damage. Lymphocytes from patients with ataxia telangiectasia (AT) show high levels of spontaneous chromosome damage and are hypersensitive to ionising radiations and it was of interest to examine the levels of SCE induced in these cells by various mutagens. The frequencies of SCE after treatment with X-rays or three chemical mutagens were equivalent to those in normal cells. The effects of fluorodeoxyuridine and deoxycytidine on SCE frequencies were also tested

Additional details

Identifiers

DOI
10.1016/0027-5107(77)90144-0;

Publishing Information

Journal Title
Mutation Research
Journal Volume
45
Journal Issue
3
Series
Mutat. Res.
Journal Page Range
343-349
ISSN
0027-5107

INIS

Country of Publication
Netherlands
Country of Input or Organization
Netherlands
INIS RN
9373479
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL REPAIR; BUDR; CELL CULTURES; CHROMATIDS; CHROMOSOMAL ABERRATIONS; DISEASES; DNA; FUDR; LYMPHOCYTES; MUTAGENS; MUTATION FREQUENCY; RADIOSENSITIVITY; X RADIATION
Descriptors DEC
ANIMAL CELLS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; AZINES; BIOLOGICAL MATERIALS; BIOLOGICAL RECOVERY; BLOOD; BLOOD CELLS; BODY FLUIDS; BROMOURACILS; CONNECTIVE TISSUE CELLS; DRUGS; ELECTROMAGNETIC RADIATION; FLUOROURACILS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IONIZING RADIATIONS; LEUKOCYTES; MUTATIONS; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC BROMINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PYRIMIDINES; RADIATIONS; RADIOSENSITIZERS; RESPONSE MODIFYING FACTORS; RIBOSIDES; SOMATIC CELLS; URACILS

Optional Information

Notes
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