Review on in vivo radionuclide generators for diagnostic and therapy

Conventional methods of radiotherapy have often been limited by physical drawbacks, use nuclides with high decay energies and short half-lives, and radionuclide loss resulting in dose to non-target tissue while circulating in the blood. To overcome these limitations, a novel approach for radiotherapy is use of parent isotopes with low energy-emitting and longer-lives of therapeutic isotopes. In conclusion, the advantage of in vivo generators is to enhance to diagnose and treatment condition with combine nuclear and chemical properties of the parent and daughter nuclides.