Published January 23, 1973 | Version v1
Report Metadata-only

The ultrastructural changes in the small intestine epithelium of mice after 1,000 rad whole-body irradiation and administration of radioprotective substances

Creators

Description

The effectivity of the radiation protection agents aminoethylisothiuronium (AET), thiamintetrahydrofurfuryldisulfide (TTFD), and S-vinyl-mercaptal-N-vinyl-pyrrolidon-copolymerisate in the eptihelium cells of the small intestine of mice is studied, and the ultrastructural changes found are compared with epithelium cells of the small intestine of control animals irradiated without any previous treatment. With AET, the structural changes after irradiation with 800 and 1,000 rad were smallest, and there was an earlier and more complete renormalization of all cell components. A comparison between the results obtained with TTFD and PVP-copolymerisate shows a more pronounced structure conservation effect of PVP-copolymerisate than of TTFD. (GSE/AK)

Abstract (German)

Es wird die Effektivitaet der Strahlenschutzsubstanzen Aminoaethylisothiuronium (AET), Thiamintetrahydrofurfuryldisulfid (TTFD) und S-Vinyl-Mercaptal-N-Vinyl-Pyrrolidon-Copolymerisat an den Duenndarmepithelwellen der Maus untersucht und die ultrstrukturell nachweisbaren Veraenderungen mit Duenndarmepithelwellen nicht vorbehandelter bestrahlter Kontrolltiere verglichen. Bei Gabe von AET sind nach einer Bestrahlung sowohl mit 800 rad als auch mit 1.000 rad die strukturellen Veraenderungen am geringsten, und es ist eine fruehere und vollstaendigere Normalisierung aller Zellkomponenten festzustellen. Der Vergleich zwischen den beim TTFD und PVP-Copolymerisat erhobenen Befunden ergibt eine bessere Wirksamkeit des PVP-Copolymerisats auf die Strukturerhaltung als dies beim TTFD der Fall ist. (GSE)

Additional details

Additional titles

Original title (German)
Die ultrastrukturellen Veraenderungen am Duenndarmepithel von Maeusen nach einer 1.000 rad

Publishing Information

Imprint Pagination
89 p.

INIS

Country of Publication
Germany
Country of Input or Organization
Germany
INIS RN
7260104
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Thesis, Non-conventional Literature
Descriptors DEI
AET; COBALT 60; DISULFIDES; EPITHELIUM; GAMMA RADIATION; MICE; PVP; RADIATION DOSES; RADIATION PROTECTION; SMALL INTESTINE; THIAMINE; THIOLS; WHOLE-BODY IRRADIATION
Descriptors DEC
AMIDES; AMINES; ANIMALS; AZINES; AZOLES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD SUBSTITUTES; BODY; CARBONIC ACID DERIVATIVES; COBALT ISOTOPES; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GASTROINTESTINAL TRACT; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTO; INTESTINES; IONIZING RADIATIONS; IRRADIATION; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LACTAMS; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC POLYMERS; ORGANIC SULFUR COMPOUNDS; ORGANS; POLYMERS; POLYVINYLS; PYRIMIDINES; PYRROLES; PYRROLIDONES; RADIATIONS; RADIOISOTOPES; RADIOPROTECTIVE SUBSTANCES; RESPONSE MODIFYING FACTORS; RODENTS; THIAZOLES; THIOUREAS; TISSUES; VERTEBRATES; VITAMIN B GROUP; VITAMINS; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
35 figs.; 68 refs. Available from ZAED.