Published October 1986 | Version v1
Journal article Metadata-only

Preparation of 2-18F-fluoro-2-deoxy-D-glucose by nucleophilic substitution with tandem accelerator produced 18F-fluoride

Creators

  • 1. Helsinki Univ. (Finland). Dept. of Radiochemistry
  • 2. Helsinki Univ. (Finland). Accelerator Lab.
  • 3. Helsinki Univ. Central Hospital (Finland)

Description

The use of the nuclear reaction 18O(p,n)18F and 18O-water targets has recently drawn an increased interest in the production of 18F-fluoride to be used in labelling radiopharmaceuticals for positron tomography. We have developed a small volume target system of nickel for effective production of 18F-fluoride. A remote controlled apparatus was constructed for the production of 2-18F-fluoro-2-deoxy-D-glucose (2-18F-FDG). The overall yield ranged from 15 -40 %, with a synthesis time of about 90 min. (author)

Additional details

Publishing Information

Journal Title
J. Labelled Compd. Radiopharm.
Journal Volume
23
Journal Issue
10-12
Series
J. Labelled Compd. Radiopharm.
Journal Page Range
1098-1099
ISSN
0362-4803
CODEN
JLCRD

Conference

Title
6. international symposium on radiopharmaceutical chemistry.
Dates
29 Jun - 3 Jul 1986.
Place
Boston, MA (USA).

INIS

Country of Publication
United Kingdom
Country of Input or Organization
United Kingdom
INIS RN
18081952
Subject category
S38: RADIATION CHEMISTRY, RADIOCHEMISTRY AND NUCLEAR CHEMISTRY;
Resource subtype / Literary indicator
Conference
Descriptors DEI
CHEMICAL PREPARATION; FLUORINE 18; FLUORODEOXYGLUCOSE; LABELLING; POSITRON COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; REMOTE CONTROL; TANDEM ELECTROSTATIC ACCELERAT
Descriptors DEC
ACCELERATORS; ANTIMETABOLITES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; COMPUTERIZED TOMOGRAPHY; CONTROL; DRUGS; ELECTROSTATIC ACCELERATORS; EMISSION COMPUTED TOMOGRAPHY; FLUORINE ISOTOPES; HOURS LIVING RADIOISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LIGHT NUCLEI; MATERIALS; NUCLEI; ODD-ODD NUCLEI; RADIOACTIVE MATERIALS; RADIOISOTOPES; SYNTHESIS; TOMOGRAPHY