Published October 2018 | Version v1
Journal article Metadata-only

Troubleshooting for F-18 fluorocholine synthesis: an institutional experience

Creators

  • 1. Department of Nuclear Medicine and PET, Post Graduate Institute of Medical Education and Research, Chandigarh (India)
  • 2. Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neuroscience, Bengaluru (India)

Description

Choline is a natural substrate for phospholipid synthesis. F-18 labeled fluorocholine nowadays is routinely used for imaging brain tumors, parathyroid adenoma, and prostate cancer. It is synthesized through nucleophilic substitution reaction using dibromomethane and N, N-dimethylaminoethanol as primary and secondary precursors, respectively. However, sometimes, failures are encountered in F-18 fluorocholine production. Few problems and troubleshooting during synthesis are discussed here. (author)

Additional details

Identifiers

DOI
10.4103/ijnm.IJNM_85_18;

Publishing Information

Journal Title
Indian Journal of Nuclear Medicine
Journal Volume
33
Journal Issue
4
Journal Page Range
p. 355-358
ISSN
0972-3919

INIS

Country of Publication
India
Country of Input or Organization
India
INIS RN
52078431
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BRAIN; CHOLINE; FLUORINE 18; NEOPLASMS; PROSTATE; RADIOISOTOPE SCANNING
Descriptors DEC
ALCOHOLS; AMMONIUM COMPOUNDS; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DISEASES; DRUGS; FLUORINE ISOTOPES; GLANDS; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; LIPOTROPIC FACTORS; MALE GENITALS; NANOSECONDS LIVING RADIOISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; QUATERNARY AMMONIUM COMPOUNDS; RADIOISOTOPES