Published November 2002 | Version v1
Journal article Metadata-only

Enhancement of the relative uptake of 18F-FDG in mouse fibrosarcoma by rolipram

Creators

  • 1. Osaka Univ., Suita (Japan). School of Allied Health Science
  • 2. National Inst. of Radiological Sciences, Chiba (Japan)
  • 3. Kyoto Prefectural Univ. of Medicine (Japan)

Description

The effect of rolipram, a selective phosphodiesterase type 4 inhibitor, on the uptake of 18F-fluorodeoxyglucose (18F-FDG) in tumor tissue was examined in mice transplanted with NFSa fibrosarcoma. The uptake indexes of 18F-FDG in the heart, skeletal muscle and brain remarkably decreased after treatment with 3 mg/kg of rolipram (heart: 13%, skeletal muscle: 14%, brain: 31%), but fibrosarcoma tissue showed only a 50% reduction in the uptake index of 18F-FDG. The tumor/muscle ratio of radioactivity 30 min after 18F-FDG injection was consequently enhanced from 1.9 to 6.5 by rolipram. This indicates the possible use of rolipram to enhance the sensitivity of tumor detection, as well as characterization of tumors in 18F-FDG PET. (author)

Additional details

Publishing Information

Journal Title
Annals of Nuclear Medicine
Journal Volume
16
Journal Issue
7
Journal Page Range
p. 507-510
ISSN
0914-7187

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
34017588
Subject category
S62: RADIOLOGY AND NUCLEAR MEDICINE;
Descriptors DEI
BLOOD PLASMA; BRAIN; ENZYME INHIBITORS; FIBROSARCOMAS; FLUORINE 18; FLUORODEOXYGLUCOSE; HEART; HOURLY VARIATIONS; MICE; MUSCLES; PYRROLIDINES; SCINTILLATION COUNTING; UPTAKE
Descriptors DEC
AMINES; ANIMALS; ANTIMETABOLITES; AZOLES; BETA DECAY RADIOISOTOPES; BETA-PLUS DECAY RADIOISOTOPES; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COUNTING TECHNIQUES; DISEASES; DRUGS; FLUORINE ISOTOPES; HETEROCYCLIC COMPOUNDS; HOURS LIVING RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LIGHT NUCLEI; MAMMALS; MATERIALS; NANOSEC LIVING RADIOISOTOPES; NEOPLASMS; NERVOUS SYSTEM; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; PYRROLES; RADIOISOTOPES; RODENTS; SARCOMAS; VARIATIONS; VERTEBRATES