Radiosynthesis of 18F-fluoroethylated tracers via a simplified one-pot 18F-fluoroethylation method using [18F]fluoroethyl tosylate

Highlights: • The simplified one-pot ¹⁸F-fluoroethylation method has developed. • The radiosynthesis of [¹⁸F]FEDAC and [¹⁸F]FET were simplified. • A lower cost of the precursors for ¹⁸F-fluoroethylation is provided. • A shorter synthesis time for ¹⁸F-fluoroethylation is provided. • Automated one-pot ¹⁸F-fluoroethylation strategy is provided. Recently, a straightforward one-pot method for ¹⁸F-fluoroethylation without azeotropic drying of cyclotron-produced [¹⁸F]F⁻ was developed. In this study, we have attempted to simplify the automated radiosynthesis of two [¹⁸F]fluoroethylated tracers, [¹⁸F]FEDAC and [¹⁸F]FET, using a desmethyl labeling precursor and [¹⁸F]fluoroethyl tosylate, based on the above-mentioned method. The radiochemical yields of [¹⁸F]FEDAC and [¹⁸F]FET were 26 ± 3.7% (n = 5) and 14 ± 2.2% (n = 4), respectively, based on total [¹⁸F]F⁻ at the end of irradiation.