Progress of 99Tc-methylenediphosphonate in clinical applications

The main ingredient of 99Tc-methylenediphosphonate (99Tc-MDP) is chelates which formed by the technetium 99Tc after stannous reduction and methylenediphosphonate. Studies have shown that 99TcMDP can inhibit the inflammatory response, play anti-inflammatory, anti-rheumatic effect, it also have significant analgesic effect by inhibit prostaglandin synthesis. In addition, 99Tc-MDP also can regulate the body' s own immune and bone metabolism to treat the corresponding diseases. Treating rheumatoid arthritis,ankylosing spondylitis, Graves' ophthalmopathy and other autoimmune diseases. It also has a good effect on pain which is caused by cancer, femoral head necrosis and osteoporosis. Review progress of 99Tc-MDP in clinical applications. (authors)