Presence of organophosphate esters in plasma of patients with hypertension in Hubei Province, China

Organophosphate esters (OPEs) are widely used as fire retardants, so they are almost ubiquitous pollutants. Recent studies had found that OPEs were detectable in human blood samples. However, the studies on the presence of OPEs in hypertensive patients were limited. In this study, 12 OPEs were detected and analyzed in plasma samples collected from hypertensive patients (case group) and unpaid blood donors (control group). The values of ∑12 OPEs concentrations ranged from ND to 8.84 μg/L and ND to 20.11 μg/L in the case group and control group, respectively, with the average concentrations of 0.62 μg/L and 1.46 μg/L, respectively. Triethyl phosphate (TEP) was detected as the most abundant chemical in the case group while triphenyl phosphate (TPHP) in the control group. Correlation analysis showed that there was a significant correlation among OPEs. The correlation coefficients and principal component analysis (PCA) indicated different sources and/or metabolism existed between the case group and control group. Diastolic blood pressure (DBP) was associated with TEP concentration (p < 0.05) in hypertensive patients. Clustering analysis showed that a trend of OPEs exposure and hypertension. This study provided data on the composition profile of OPEs in plasma and human exposure to OPEs, which was the first to identify the association of OPEs with hypertension.