Published August 1989
| Version v1
Journal article
Encapsulation of the UV-DNA repair enzyme T4 endonuclease V in liposomes and delivery to human cells
Creators
- 1. Applied Genetics Inc., Freeport, NY (USA)
Description
T4 endonuclease V, a pyrimidine-dimer-specific DNA repair enzyme, was encapsulated in liposomes under mild conditions. The encapsulated enzyme was active, and when applied to ultraviolet (UV)-irradiated human cells in culture, the liposomes increased incision of UV-irradiated cellular DNA, enhanced DNA repair replication, and enhanced survival of UV-irradiated cells. This method is a first step in a new approach for topical application of DNA repair enzymes to human skin to prevent skin cancer
Additional details
Publishing Information
- Journal Title
- Journal of Investigative Dermatology
- Journal Volume
- 93
- Journal Issue
- 2
- Series
- J. Invest. Dermatol.
- Journal Page Range
- 190-194
- ISSN
- 0022-202X
- CODEN
- JIDEA
INIS
- Country of Publication
- United States
- Country of Input or Organization
- United States
- INIS RN
- 21005875
- Subject category
- S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
- Descriptors DEI
- CELL CULTURES; DNA; DNA REPAIR; ENCAPSULATION; ENDONUCLEASES; EPIDERMIS; FIBROBLASTS; GENETIC RADIATION EFFECTS; KERATIN; LIPOSOMES; MAN; SURVIVAL TIME; ULTRAVIOLET RADIATION
- Descriptors DEC
- ANIMAL CELLS; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; BODY; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; ENZYMES; EPITHELIUM; ESTERASES; GENETIC EFFECTS; HYDROLASES; MAMMALS; NUCLEASES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PHOSPHODIESTERASES; PRIMATES; PROTEINS; RADIATION EFFECTS; RADIATIONS; SCLEROPROTEINS; SKIN; SOMATIC CELLS; TISSUES; VERTEBRATES