Published June 1980 | Version v1
Journal article Metadata-only

Ultraviolet light-induced transformation of human cells to anchorage-independent growth

Creators

  • 1. Brookhaven National Lab., Upton, NY

Description

We have developed a system for ultraviolet light (uv) irradiations, post irradiation growth, and plating in soft agar. The cells show crisscrossing and piling up; they reach 2- to 5-fold higher saturation densities than the parental cells. The susceptibility of the uv transformation process to apparent photoenzymatic reversal implies that pyrimidine dimers play a role in its induction

Additional details

Publishing Information

Journal Title
Cancer Res.
Journal Volume
40
Journal Issue
6
Series
Cancer Res.
Journal Page Range
1934-1939
ISSN
0008-5472

INIS

Country of Publication
United States
Country of Input or Organization
United States
INIS RN
12595465
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Descriptors DEI
BIOLOGICAL RADIATION EFFECTS; CARCINOGENESIS; DIMERS; EMBRYONIC CELLS; GROWTH; MAN; PHOTOREACTIVATION; PYRIMIDINES; ULTRAVIOLET RADIATION
Descriptors DEC
ANIMAL CELLS; ANIMALS; AZINES; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; MAMMALS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PATHOGENESIS; PRIMATES; RADIATION EFFECTS; RADIATIONS; VERTEBRATES