Published June 2010 | Version v1
Report Metadata-only

Analysis of DNA damage response using by heavy ion beam in induced pluripotent stem cell

Creators

  • 1. Kyoto Univ., Radiation Biology Center, Kyoto, Kyoto (Japan)
  • 2. National Inst. of Radiological Sciences, Chiba, Chiba (Japan)

Description

Stem cells have high efficiency of chromosomal recombination but the mechanism is still unclear. In this study, we investigated the cell sensitivity to several DNA damage treatments such as High/Low linear energy transfer (LET) radiation and other DNA damaging agents in stem and differentiated cells. In recent studies, we found that plagl1-positive glioma stem cells showed resistance to mitomycin C, whose damage is repaired by homologous recombination. This finding suggests that plagl1-induced dedifferentiation might increase homologous recombination activity. (author)

Part of:
2009 annual report of the research project with heavy ions at NIRS-HIMAC

Additional details

Identifiers

URL
http://id.nii.ac.jp/1657/00073735/;

Publishing Information

Imprint Title
2009 annual report of the research project with heavy ions at NIRS-HIMAC
Imprint Pagination
338 p.
Journal Page Range
p. 156-157
Report number
NIRS-M--234

INIS

Country of Publication
Japan
Country of Input or Organization
Japan
INIS RN
53066989
Subject category
S63: RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS;
Resource subtype / Literary indicator
Non-conventional Literature
Descriptors DEI
CARBON IONS; CESIUM 137; DNA DAMAGES; DNA REPAIR; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; GENETIC RADIATION EFFECTS; GLIOMAS; HEAVY IONS; MITOMYCIN; STEM CELLS; SURVIVAL CURVES; TUMOR CELLS
Descriptors DEC
ANIMAL CELLS; ANTIBIOTICS; ANTI-INFECTIVE AGENTS; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL RECOVERY; BIOLOGICAL REPAIR; CESIUM ISOTOPES; CHARGED PARTICLES; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; GENETIC EFFECTS; INTERMEDIATE MASS NUCLEI; IONIZING RADIATIONS; IONS; ISOTOPES; NEOPLASMS; NERVOUS SYSTEM DISEASES; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; REPAIR; SOMATIC CELLS; YEARS LIVING RADIOISOTOPES

Optional Information

Notes
This record replaces 45037396
Secondary number(s)
HIMAC--134