Brain uptake of halogenated products of D-glucal

Halogenated products of D-glucal were obtained on direct addition of halogens (36Cl and 82Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. The brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and the usable activity from D-glucal dihalides is twice as much as those from equal moles of 18F-2-deoxy-2-fluoro-D-glucose and 18F-3-fluoro-D-glucose. D-glucal can be readily available for months without any detectable chemical alteration. (author)