Published 1979 | Version v1
Journal article Metadata-only

Problems encountered during intensive routine scale performance of paper T4 and TSH radioimmunoassays

Creators

  • 1. Hopital Cochin, 75 - Paris (France)

Description

High sensitivity attained in radioimmunoassays explains the important role played by specialized laboratories as screening partners for early neonatal hypothyroidism detection. In this paper, the author tries to point out optimal technical conditions to be followed while performing at routine scale T4 and TSH paper immunoassays choice of filter paper, blood collection and storage, assay, quality control, assay mecanization, computer calculation of results

Abstract (French)

L'extreme sensibilite des dosages radioimmunologiques adaptes a des volumes tres reduits de sang total a porte les laboratoires en premiere ligne du depistage de l'hypothyroidie neonatale. Dans l'expose qui suit, nous abordons successivement l'analyse des conditions optimales du recueil et du stockage des echantillons, l'etude des protocoles experimentaux, le controle de qualite et l'etat actuel de l'automatisation des dosages en grandes series. Il s'agit essentiellement d'une contribution a la preparation d'un dossier technique, destine a preciser certaines normes indispensables a la fiabilite du depistage biologique

Additional details

Additional titles

Original title (French)
Etude critique des problemes associes a la pratique en grande serie des dosages radioimmunologiques de T4 et de TSH sur papier

Publishing Information

Journal Title
Ann. Endocrinol. (Paris)
Journal Volume
40
Journal Issue
4
Series
Ann. Endocrinol. (Paris).
Journal Page Range
461-467
ISSN
0003-4266

INIS

Country of Publication
France
Country of Input or Organization
France
INIS RN
11521975
Subject category
S60: APPLIED LIFE SCIENCES;
Descriptors DEI
AUTOMATION; OPTIMIZATION; QUALITY CONTROL; RADIOIMMUNOASSAY; THYROXINE; TSH
Descriptors DEC
AMINO ACIDS; CARBOXYLIC ACIDS; CONTROL; HORMONES; ISOTOPE APPLICATIONS; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC IODINE COMPOUNDS; PEPTIDE HORMONES; PITUITARY HORMONES; THYROID HORMONES; TRACER TECHNIQUES