Published February 2015 | Version v1
Journal article Metadata-only

Practical synthesis of 1-(2-Nitro-1H-imidazol-1-yl)-3-(tosyloxy)propan-2-yl acetate for the radiosynthesis of [18F]-FMISO

Creators

  • 1. Dept. of Nuclear Medicine, Molecular Imaging and Therapeutic Medicine Rese arch Center, CyclotronResearch Center, Biomedica l Research Institute, Chonbuk National University Medical School and Hospital,Jeonju (Korea, Republic of)
  • 2. Dept. of Chemistry and Research Institute of Physics and Chemistry, Chonbuk National University,Jeonju (Korea, Republic of)
  • 3. Dept. of Chemistry Chemical Engineering, Korea University of Technology and Education (KOREATECH),Cheonan (Korea, Republic of)

Description

Hypoxia is related with many tumors due to a decreased oxygen condition. Novel synthesis for 1-(2-nitro-1H-imidazol-1-yl)-3-(tosyloxy)propan-2-yl acetate for the radiosynthesis of the [18F]-Flouromisonidazole ([18F]-FMISO), a hypoxia imaging marker used in positron emission tomography, from the readily available starting material is described. In this approach, one-pot two-step syntheses were used for the preparation of the [18F]-FMISO precursors that contain acetyl group. The mild reaction conditions and easy treatments are attractive features in this synthesis. This new synthetic route provides alternative choices for the preparation of hypoxia imaging marker

Additional details

Publishing Information

Journal Title
Bulletin of the Korean Chemical Society
Journal Volume
36
Journal Issue
2
Series
14 refs, 4 figs
Journal Page Range
p. 559-563
ISSN
0253-2964

INIS

Country of Publication
Korea, Republic of
Country of Input or Organization
Korea, Republic of
INIS RN
48066766
Subject category
S37: INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY;
Descriptors DEI
ANOXIA; IMAGES; NEOPLASMS; OXYGEN; POSITRON COMPUTED TOMOGRAPHY; SYNTHESIS
Descriptors DEC
COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; ELEMENTS; EMISSION COMPUTED TOMOGRAPHY; NONMETALS; TOMOGRAPHY